Four siblings with horribly selfish parents hatch a plan to get rid of them for good and form a perfectly imperfect family of their own.

The series is a prequel, featuring the high school years of Flint Lockwood, the eccentric young scientist in the films. In his adventures, he will be joined by Sam Sparks, a new girl in town and the school's "wannabe" reporter, along with Flint's dad Tim, Steve the Monkey, Manny as the head of the school's audiovisual club, Earl as a school gym teacher, Brent as a baby wear model, and Mayor Shelbourne, who wins every election on the pro-sardine platform.