In an alternate world, humanity and vampires have warred for centuries. After the last Vampire War, the veteran Warrior Priest lives in obscurity with other humans inside one of the Church's walled cities. When the Priest's niece is kidnapped by vampires, the Priest breaks his vows to hunt them down. He is accompanied by the niece's boyfriend, who is a wasteland sheriff, and a former Warrior Priestess.

When God loses faith in humankind, he sends his legion of angels to bring on the Apocalypse. Humanity's only hope for survival lies in a group of strangers trapped in an out-of-the-way, desert diner with the Archangel Michael.