Detective Catherine Chandler is a smart, no-nonsense homicide detective. When she was a teenager, she witnessed the murder of her mother at the hands of two gunmen and herself was saved by someone – or something. Years have passed and while investigating a murder, Catherine discovers a clue that leads her to Vincent Keller, who was reportedly killed in 2002. Catherine learns that Vincent is actually still alive and that it was he who saved her many years before. For mysterious reasons that have forced him to live outside of traditional society, Vincent has been in hiding for the past 10 years to guard his secret – when he is enraged, he becomes a terrifying beast, unable to control his super-strength and heightened senses.

The story revolves around a new high school student, Jo (Meaghan Martin) , who agrees to befriend an outcast, Abby (Jennifer Stone), at the urging of Abby's wealthy father in exchange for paying all of Jo's costs for the college of her dreams. Jo and Abby team up to take on the school's mean girls, the Plastics.