In an attempt to rectify their criminal past, a once successful Hollywood starlet, turn prostitute, and a petty, misogynistic thief, set out together to solve a high profile child abduction case in San Francisco.

Picking up directly where the previous film left off, the story follows Riley, one of the last people to come in contact with Samantha, as he scrambles to track down those responsible for the outbreak before the highly contagious disease not only consumes his body, but the world as we know it.