Follow a new generation of the Dutton family during the early twentieth century when pandemics, historic drought, the end of Prohibition and the Great Depression all plague the mountain west, and the Duttons who call it home.

There's a new Ghostface in town terrorizing teens, 25 years after Woodsboro's first killing spree — and old friends must reunite to stop the slaughter.

Primatologist Davis Okoye shares an unshakable bond with George, the extraordinarily intelligent, silverback gorilla who has been in his care since birth. But a rogue genetic experiment gone awry mutates this gentle ape into a raging creature of enormous size. To make matters worse, it’s soon discovered there are other similarly altered animals. As these newly created alpha predators tear across North America, destroying everything in their path, Okoye teams with a discredited genetic engineer to secure an antidote, fighting his way through an ever-changing battlefield, not only to halt a global catastrophe but to save the fearsome creature that was once his friend.

Sidney Prescott, now the author of a self-help book, returns home to Woodsboro on the last stop of her book tour. There she reconnects with Sheriff Dewey and Gale, who are now married, as well as her cousin Jill and her Aunt Kate. Unfortunately, Sidney's appearance also brings about the return of Ghostface, putting Sidney, Gale, and Dewey, along with Jill, her friends, and the whole town of Woodsboro in danger.

A favor for a woman from her past throws the life of a pregnant, retired porn star into chaos.