A man, Fallon (Alex Pettyfer) roams the land as a creature of the night as he comes to terms with tragic loss of his family at the hands of a brutal demagogue, Reynolds (Guy Pearce).

A hybrid creature - half piranha and half anaconda -- attacks a low-budget horror movie crew on location near her nest when her egg is stolen. Now they must outrun and kill the deadly piranhaconda as well as stop the mad scientist who stole the egg - before they all become dinner.