Best friends for life, Jane and Fiona have done everything together since kindergarten – Jane following wherever Fiona will lead. Left devastated and adrift following Fiona’s sudden suicide, Jane’s only way to make sense of everything is by helping Fiona’s widow Gemma care for their young son Bailey. Polar-opposites, the two women have nothing in common save for their shared grief and love for Fiona.

Picking up directly where the previous film left off, the story follows Riley, one of the last people to come in contact with Samantha, as he scrambles to track down those responsible for the outbreak before the highly contagious disease not only consumes his body, but the world as we know it.