When a wicked guinea pig captures Superman, the hero's loyal Labrador recruits a crew of extraordinary shelter pets to save the day.

The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."

With her widower father currently living it up in Paris with a young, new girlfriend, Lilian has been placed into the care of family friends over in Brooklyn, New York. Under the roof of famed author, Julia Price, Lilian has no real motivation to live any other lifestyle than that of her hermit housemate. To impress her ex-boyfriend, and the other cynics around her, Lilian suddenly decides to make a documentary on Julia - albeit, an unauthorized one - with the help of some new people in her life.

A legendary late-night talk show host's world is turned upside down when she hires her only female staff writer. Originally intended to smooth over diversity concerns, her decision has unexpectedly hilarious consequences as the two women separated by culture and generation are united by their love of a biting punchline.