The modern world holds many secrets, but by far the most astounding is that witches still live among us; vicious supernatural creatures intent on unleashing the Black Death upon the world and putting an end to the human race once and for all. Armies of witch hunters have battled this unnatural enemy for centuries, including Kaulder, a valiant warrior who many years ago slayed the all-powerful Witch Queen, decimating her followers in the process. In the moments right before her death, the Queen cursed Kaulder with immortality, forever separating him from his beloved wife and daughter. Today, Kaulder is the last living hunter who has spent his immortal life tracking down rogue witches, all the while yearning for his long-lost family.

A preacher sets out on a mission to make the almighty himself confess his sin of abandoning the world. With his best friend Cassidy, an alcoholic Irish vampire, his love Tulip, a red blooded gun towing Texan, and the power of genesis, an unholy child born from an angel and a devil, Jesse gives up everything to set the world straight with its creator.