Ji Sun Woo is a family medicine doctor. She is married to Lee Tae Oh and they have a son. She seems to have everything, including a successful career and a happy family, but she is betrayed by her husband and others. Meanwhile Lee Tae Oh dreams of becoming a famous movie director. He runs an entertainment business with the support of his wife Ji Sun Woo. Even though he loves his wife, Lee Tae Oh falls into a dangerous relationship.

Heirs follows a group of privileged, elite high school students as they are groomed to take over their families' business empires. These wealthy students seem to have everything under control–except their love lives. Kim Tan is heir to the Empire Group sent to study abroad in the U.S. In reality it's a form of exile, as his elder half-brother back home schemes to takes over the family business. While in the States, Kim Tan bumps into Cha Eun Sung, who's arrived from Korea in search of her older sister. He feels himself falling for her, never realizing that she's the daughter of his family's housekeeper. When his fiancée Rachel Yoo arrives to bring him back to Korea, his heart is torn between love and duty. Meanwhile, Rachel's half-brother Choi Young Do develops his own crush on Eun Sung. Who said being a rich, beautiful high school student was easy?