The Russo family and friends are headed to Tuscany, Italy, to meet their long lost relatives... but when Alex tries to prove she's more than a seemingly carefree young Wizard, she inadvertently conjures a spell that creates a Good Alex and an Evil Alex. When Evil Alex gets roped into a charming young wizard's foreboding plan to take over the world, Good Alex must find a way to save her family and humankind, which leads to a monumental battle between the two versions of herself - all atop the Tower of Pisa.

The story revolves around a new high school student, Jo (Meaghan Martin) , who agrees to befriend an outcast, Abby (Jennifer Stone), at the urging of Abby's wealthy father in exchange for paying all of Jo's costs for the college of her dreams. Jo and Abby team up to take on the school's mean girls, the Plastics.