A new chapter in Jean-Luc Picard's life set twenty years after the events of Star Trek Nemesis.

En route to the honeymoon of William Riker to Deanna Troi on her home planet of Betazed, Captain Jean-Luc Picard and the crew of the U.S.S. Enterprise receives word from Starfleet that a coup has resulted in the installation of a new Romulan political leader, Shinzon, who claims to seek peace with the human-backed United Federation of Planets. Once in enemy territory, the captain and his crew make a startling discovery: Shinzon is human, a slave from the Romulan sister planet of Remus, and has a secret, shocking relationship to Picard himself.

When an alien race and factions within Starfleet attempt to take over a planet that has "regenerative" properties, it falls upon Captain Picard and the crew of the Enterprise to defend the planet's people as well as the very ideals upon which the Federation itself was founded.

The Borg, a relentless race of cyborgs, are on a direct course for Earth. Violating orders to stay away from the battle, Captain Picard and the crew of the newly-commissioned USS Enterprise E pursue the Borg back in time to prevent the invaders from changing Federation history and assimilating the galaxy.