In the near future, a weary Logan cares for an ailing Professor X in a hideout on the Mexican border. But Logan's attempts to hide from the world and his legacy are upended when a young mutant arrives, pursued by dark forces.

A small town is suddenly and inexplicably sealed off from the rest of the world by an enormous transparent dome. While military forces, the government and the media positioned outside of this surrounding barrier attempt to break it down, a small group of people inside attempt to figure out what the dome is, where it came from, and when (and if) it will go away.