As the human species adapts to a synthetic environment, the body undergoes new transformations and mutations. Accompanied by his partner Caprice, celebrity performance artist Saul Tenser showcases the metamorphosis of his organs. Meanwhile, a mysterious group tries to use Saul's notoriety to shed light on the next phase of human evolution.

Fed up with their families and classmates, two teen girls from a wealthy part of Rome are drawn to the city's underworld and start leading double lives.