There's a new Ghostface in town terrorizing teens, 25 years after Woodsboro's first killing spree — and old friends must reunite to stop the slaughter.

Lakshmi is a thirteen-year-old girl who lives with her family in a small hut on a mountain in Nepal. When the Himalayan monsoons wash away all that remains of the family's crops, Lakshmi's father says she must leave home and take a job to support her family. He introduces her to a glamorous stranger who tells her she will find her a job as a maid in the city. Glad to be able to help, Lakshmi journeys to India and arrives at "Happiness House" full of hope. But she soon learns the unthinkable truth: she has been sold into prostitution...

Sidney Prescott, now the author of a self-help book, returns home to Woodsboro on the last stop of her book tour. There she reconnects with Sheriff Dewey and Gale, who are now married, as well as her cousin Jill and her Aunt Kate. Unfortunately, Sidney's appearance also brings about the return of Ghostface, putting Sidney, Gale, and Dewey, along with Jill, her friends, and the whole town of Woodsboro in danger.