Three American guys who perpetually strike out with the ladies travel to Europe and embark on an adventure through the continent filled with drinking, dancing, and partying while dodging gypsies, gangsters, and soccer hooligans to get to the world's hottest club.

Phil and his misfit friends score big when they are invited to the party of the century at Bob's house. Known for throwing the craziest drug, sex and booze filled parties, this was sure to be a night to remember. The only problem is that they can't remember a thing. When Phil wakes up realizing that his girlfriend is only hours from knocking on his door, he decides to enlist the help of his friends to try to piece together what was obviously a night worth remembering.