Vicaria is a brilliant teenager who believes death is a disease that can be cured. After the brutal and sudden murder of her brother, she embarks on a dangerous journey to bring him back to life.

On the run from a lethal assassin, a wily con artist devises a scheme to hide out inside a small-town police station-but when the hitman turns up at the precinct, an unsuspecting rookie cop finds herself caught in the crosshairs.

Britt Reid (Seth Rogen), the heir to the largest newspaper fortune in Los Angeles, is a spoiled playboy who has been, thus far, happy to lead an aimless life. After his father (Tom Wilkinson) dies, Britt meets Kato (Jay Chou), a resourceful company employee. Realizing that they have the talent and resources to make something of their lives, Britt and Kato join forces as costumed crime-fighters to bring down the city's most-powerful criminal, Chudnofsky (Christoph Waltz).