An exhausted, workaholic actress, Anna Baskin, 44, abruptly extricates herself from a successful but mind-numbing TV role, returning to her past life in New York to reinvent herself.

I Origins follows a molecular biologist studying the evolution of the human eye. He finds his work permeating his life after a brief encounter with an exotic young woman who slips away from him. As his research continues years later with his lab partner, they make a stunning scientific discovery that has far reaching implications and complicates both his scientific and and spiritual beliefs. Traveling half way around the world, he risks everything he has ever known to validate his theory.

In the crime-ridden slums of New York in the 1860s, vengeful orphan Amsterdam Vallon joins the cutthroat gang of his father's killer, Bill the Butcher.