Gru, Lucy, Margo, Edith, and Agnes welcome a new member to the family, Gru Jr., who is intent on tormenting his dad. Gru faces a new nemesis in Maxime Le Mal and his girlfriend Valentina, and the family is forced to go on the run.

A fanboy of a supervillain supergroup known as the Vicious 6, Gru hatches a plan to become evil enough to join them, with the backup of his followers, the Minions.