Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

While still out to destroy the evil Umbrella Corporation, Alice joins a group of survivors living in a prison surrounded by the infected who also want to relocate to the mysterious but supposedly unharmed safe haven known only as Arcadia.

A successful executive with the perfect job and perfect wife finds his life falling apart when a sexy office temp sets out to seduce and destroy him.