Julia becomes worried about her boyfriend, Holt when he explores the dark urban legend of a mysterious videotape said to kill the watcher seven days after viewing. She sacrifices herself to save her boyfriend and in doing so makes a horrifying discovery: there is a "movie within the movie" that no one has ever seen before.

Sidney Prescott, now the author of a self-help book, returns home to Woodsboro on the last stop of her book tour. There she reconnects with Sheriff Dewey and Gale, who are now married, as well as her cousin Jill and her Aunt Kate. Unfortunately, Sidney's appearance also brings about the return of Ghostface, putting Sidney, Gale, and Dewey, along with Jill, her friends, and the whole town of Woodsboro in danger.